how tobacco affects the brain on Nicotine (Image: Elliot Stein, National Institute on Drug Nicotine: The Brain | Stanford

There are a few studies to draw from, but most evidence is anecdotal

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A 2019 study looked at NIH health data from 2016 and 2017, and couldnt establish a connection between vaping and heart disease, though it found evidence smoking traditional cigarettes increased the risk of heart disease

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[198] [201] Monoamine autoreceptors (e.g., D 2 short, presynaptic 2 , and presynaptic 5-HT 1A ) have the opposite effect of TAAR1, and together these receptors provide a regulatory system for monoamines