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As nicotine enhances the transcription of uPA/uPAR, it is possible that uPAR could be another clinically important player triggered by nicotine in the development of cancer [79]

If history and economics hold true, the substantial price increases should translate into reduced tobacco consumption, particularly among vulnerable populations, ultimately saving lives and reducing the healthcare burden associated with tobacco-related diseases

It does not affect vaping, which has already become more popular than smoking in New Zealand

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This chapter does not cover the various cancers caused by tobacco use