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The 3-phosphoglycerate produced can then re-enter the glycolytic pathway at the reaction catalyzed by phosphoglycerate mutase, i.e., the eighth step of the pathway

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Transient and mild stress (such as transient ischemic preconditioning) can induce moderate mitophagy to exert a protective effect, while sustained and high-intensity stress (such as long-term severe ischemia and severe oxidative stress) is prone to trigger excessive mitophagy, shifting the regulatory effect toward damage

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doi: 165

The chapter discusses the use of zebrafish models in toxicological research to investigate mitochondrial reactions to environmental stressors and xenobiotics