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First, there is a surprising lack of preclinical research examining how methylphenidate alters nicotine self-administration and vice versa, with only a single study (Wooters et al., 2008)

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Most military officers would try to do normal plans first, but Misato is all "Nope, let's go with a giant freaking laser beam." I think Gendo only went along with it because he knew that Misato would accept nothing less than the ability to shoot a giant freaking laser beam