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By contrast, upregulation of this axis protects cells from ferroptosis, and emerging data highlights specific pathways, such as the RAS pathway in oncogenic signaling, capable of enhancing GCH1 transcription and suppressing ferroptosis (84)

Rodent-model studies describe protocol-defined endpoints typically across one to four weeks

Twice-Daily Fludarabine and Cytarabine Combination With or Without Gentuzumab Ozogamicin is Effective in Patients With Relapsed/Refractory Acute Myeloid Leukemia, High-Risk Myelodysplastic Syndrome, and Blast- Phase Chronic Myeloid Leukemia