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For cancers, carcinogens in smoke can directly mutate oncogenes like p53 while also fueling tumor growth through oxidative stress (Cha et al

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For our consumers, we want to actively encourage them to migrate from cigarettes to smokeless alternatives by offering a range of enjoyable and responsibly marketed smokeless products in tobacco, nicotine and beyond

2) light smoking, defined as having smoked at least 100 cigarettes during the lifetime from the GWAS pipeline using Pheasant-derived variables from UK Biobank (GWAS ID=ukb-b-8133) ( 3) smoking initiation, as derived from a GWAS of Europeandescent individuals (GWAS ID=ieu-b-4877) 12

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" Dr Iain Kennedy, a consultant in public health, from Glasgow, called for restrictions on places where e-cigarettes can be used in public