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By reducing oxidative stress, cysteine indirectly suppresses the activation of the NF-B pathway, a key transcription factor that drives the expression of pro-inflammatory cytokines such as TNF- and IL-6 ( 2.3 GPX4 GPX4, a key enzyme in the glutathione peroxidase family, is essential for managing ferroptosis by catalyzing the reduction of lipid hydroperoxides and the conversion of GSH to glutathione disulfide (GSSG), thus preventing the lipid peroxidation associated with this form of cell death ( Drugs like RAS Selective Lethal 3 (RSL3) specifically target GPX4, binding covalently to inactivate its function, leading to a buildup of lipid hydroperoxides that can trigger ferroptosis ( GPX4 serves as a protective agent in the skin environment, contributing to skin health and vitality through its antioxidant properties

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The triple helical domains have a repeating amino acid sequence: glycine-X-Y, where X is most often proline and Y is most often hydroxyproline

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Thomson et al

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