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Ashton OB, Wong M, Mcghie TK, Vather R, Wang Y, Requejo-Jackman C, Ramankutty P, Woolf AB (2006) Pigments in avocado tissue and oil

Unquestionably, given the exceedingly high energy demands imposed upon the nigrostriatal system, it seems plausible that aging-associated energy failures might critically contribute to PD-associated neurotoxicity

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This is reflected in Pompes disease (glycogen storage disease type II), in which deficiency of this enzyme leads to progressive lysosomal glycogen buildup, impaired autophagic flux, and (cardio)myopathy 72

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