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Alternatively, PZA can be initially oxidized to 5-hydroxy-pyrazinamide (5-OH-PZA) by XO, followed by amidase-mediated hydrolysis to 5-OH-PA

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Cytokines found in the sera and skin of morphea patients in increased concentration include IL-4, IL-6, and IL-8.18 These cytokines (especially IL-4) upregulate TGF-, initiating a cascade of events resulting in increased production of collagen and other extracellular matrix components via induction of connective tissue growth factor, platelet-derived growth factor, and matrix metalloproteinases

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Allergic shock or an inflammatory reaction are two side effects of this medication in cats

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