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However, compliance in only using research cigarettes in these trials is a concern [40], and although the extent of non-compliance was small for many participants, the feasibility of a nicotine reduction strategy depends on balancing the need for reducing dependence and the incidence of tobacco-related disease and minimizing the potential harms to smokers associated with withdrawal

All quality control procedures recommended by the manufacturers were followed

This was the first year ICD-10-CM was implemented into the HIPAA code set.

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