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Specifically, we used a random intercept in the mixed-effects model to account for the within-study correlation and used a study-specific random slope with respect to the signal to capture between-study heterogeneity

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A light cigarette's filter perforated by tiny holes, for instance, is uncovered when smoked by machine, and consequently, the cigarette smoke is heavily diluted with air and causes the machines to report low levels of nicotine and tar

Ghorbani R, Malek M, Eskandarian R, Rashidy-Pour A

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These three elements make the difference between a pleasant or frustrating smoke