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A cryptic site at 0.1% relative rate has kcat/KM 10 Ms

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Isolated Langendorff-perfused explanted human hearts with extensive infarction or dilated cardiomyopathy demonstrated increased vulnerability to triggering of VT due to cardiac fibrosis facilitating re-entry mechanisms (183, 184)

It is registered under the National Drug Approval Code Z15021615, with the experimental batch number 230655 and a production date of June 30, 2023

As we suspected that the point mutations we introduced in the RING2 of ANKIB1 might not have aborted its activity to the same extent as was seen in previous studies for other RBR-E3s 22,23,24 , we next expressed an ANKIB1 mutant lacking the entire RING2 domain (ANKIB1RING2) (Extended Data Fig

In horses, folate status reflects both dietary intake and microbial synthesis in the hindgut