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After exogenous lactate intervention, primary VSMCs lost their contractile phenotype and differentiated into osteoblasts, accompanied by the increased opening rate of mitochondrial permeability transition pore, a significant decrease in MMP and mitochondrial energy generation capacity, and impaired mitochondrial biogenesis

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To date there is no complete understanding of the triggering pathomechanisms of disease, and no quantitative biomarker available with sufficient sensitivity, specificity, and adoptability to provide conclusive diagnosis

Regulatory Status FDA Category 2, PCAC Review July 2026 BPC-157 is currently FDA Category 2 meaning it cannot be legally compounded in the United States due to insufficient safety data for the FDA's compounding standards

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doi: 10.1080/07315724.2002.10719214