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Nicotine Tob Res 19(2):168175

Less weight, but more fat

While evidence of the dangers of smoking was accumulating as early as the 1930s and 1940s, the landmark moment came in 1964 when US Surgeon General Luther Terry released a report titled Smoking and Health. Surveying all of the available evidence, the report declaratively confirmed the link between smoking and lung cancer (along with other diseases)

To quantify the strength of the evidence, we calculated the ROS for each smokingoutcome association as the signed value of the log(BPRF) averaged between the 15th and 85th percentiles of observed exposure levels for each outcome

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Though e-cigarettes (or vapes) have nicotine, they dont have tobacco, so they arent taxed like regular cigarettes, as defined by state law