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Aging: As individuals age, the tissues supporting the veins can weaken

doi: 10.1007/978-1-4615-0077-3_42

Annu Rev Pharmacol Toxicol 56:361383

3 Mitophagy signaling pathways 3.1 PINK1-parkin-dependent mitophagy In 1998, Lemasters and colleagues observed that under nutrient-deprived conditions, a portion of mitochondria underwent spontaneous depolarization and were subsequently engulfed by lysosomes