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6.2 Hypoxia In the normal adult intervertebral disc (IVD), oxygen partial pressure gradually decreases from about 10% in the outer annulus fibrosus to less than 1% in the central region, placing the entire disc in a state of continuous hypoxia, which may further decrease during degeneration (Urban, 2002)

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doi: 10.1038/psp.2013.14

There is a second pathway that breaks down levodopa, via the enzyme catechol-O-methyltransferase (COMT)

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