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Doses of potentiated sulfonamides are generally higher in dogs who develop the idiosyncratic hepatic reaction, as compared with other systemic manifestations of sulfonamide hypersensitivity (thrombocytopenia, fever, polyarthropathy, other)

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Methods Study design This experimental study was conducted at the Graduate Periodontology Clinic, College of Dentistry, The Ohio State University (OSU) and was performed on healthy volunteers who received standardized buccal gingival wounds created between the maxillary right premolars and were then followed for two weeks postoperatively

Monoesters, monoamides, and diamides tested generally exhibited low in vitro activity

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