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As Polosa, Rodu, and Fagerstrm explain, harm reduction strategies aim to move people down the risk continuum away from the deadliest form of nicotine use: cigarette smoking

One reason why e-cigarette use could contribute to a high risk of cavities is the sugary content and viscosity of vaping liquid, which, when aerosolized and then inhaled through the mouth, sticks to the teeth

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This was also evidenced from the immunofluorescent staining of CS exposed wells displaying reduced tight junctions in apical alveolar epithelial cells (stained with ZO-1) and lower CD31/PECAM-1 gene and protein expression on the basal endothelial cells (Supplementary Fig