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Due to the large percentage of women utilizing nicotine products during pregnancy in the United States and globally, this review seeks to centralize pre-clinical and clinical studies focused on the neurobehavioral and neurodevelopmental complications associated with prenatal nicotine exposure (PNE) such as alterations to the hypothalamic-pituitary-adrenal (HPA) axis and brain regions such as the prefrontal cortex (PFC), ventral tegmental area (VTA), nucleus accumbens (NA), hippocampus, and caudate as well as changes to nAChR and cholinergic receptor signaling, long-term drug seeking behavior following PNE, and other related developmental disorders

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As smoking habits shift and more individuals consume fewer cigarettes than in the past, gaining a clearer understanding of their long-term heart risks and the benefits of quitting remains essential, even for those who do not come close to a pack a day

doi: 10.1172/JCI74985 91 HuXZhangHZhangQYaoXNiWZhouK