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thus, appropriate tests need to be carried out to rule out this condition if suspected

Vegetarians and vegans may need to consider B12 supplements

The barrier functions of esophageal squamous stratified epithelium involve providing mucosal and submucosal defense against noxious intraluminal substances and regulating paracellular ion transport, which is mediated by claudins, the tetra-spanning transmembrane proteins of tight junctions, located at the apical and lateral membranes of esophageal epithelial cells