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Studies reveal a decrease in Nrf2 protein expression in the prefrontal cortex (PFC) of patients with major depressive disorder (MDD), while Nrf2 knockout mice exhibit depressive-like behaviors

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Although it entered phase 1 trials in consideration as a treatment of ulcerative colitis, it has not been approved by the US Food and Drug Administration (FDA) for medical use, and data on human subjects is lacking

10.1371/journal.pone.0240616 94 YanM.ManS.LiangY.MaL.GuoL.HuangL.et al (2023)