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An impairment in mitophagy was found to be associated with cardiomyopathy, probably due to an increased number of dysfunctional mitochondria in the heart (18)

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2 Importantly, they also showed that pharmacologically inhibiting all other known cell death pathwaysincluding necroptosis (with necrostatin-1), ferroptosis (with ferrostatin-1), oxidative stress (with N-acetyl cysteine), and apoptosis (with Z-VAD-FMK)failed to suppress elesclomol-induced cell death

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BRCP/ABCG2 is reportedly responsible for multi-drug resistance due to pumping drugs out of cancer cells, and GST also contributes via the detoxification and deactivation of anticancer drugs (Arvalo et al., 2017[5]