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Finally, we critically re-evaluate clinical evidence and propose an integrated future direction, arguing that the full potential of SFN will be realized only through a precision medicine approach that accounts for the complex interplay from farm to fork, and from fork to physiology

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First, little is known about the variety of biological roles performed by NSC-derived exosomes, and it is still unclear how these exosomes connect with recipient cells to modulate target cells

However, long-lasting chronic resistive training in young adults was related to increased level of IGF1 and heart hypertrophy, but did not influence the level of circulating Klotho 48

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