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Among the components of CS, reactive oxygen species (ROS) play a crucial role in its pathogenic effects

1h, Supplementary Fig

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As sensation seeking has long been implicated in the reinforcing effects of psychostimulants 52 , we thus proposed a reinforcement loop underlying the maintenance of smoking, where smoking behaviour could reduce GMV in the right vmPFC, leading to disinhibited reward-seeking behaviour (i.e., higher sensation seeking), and hence, in turn, promote future smoking behaviour