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In the case of water deficit, osmolality of the extracellular fluids, in particular of plasma, increases above its normal value (about 280 mOsmol/kg H2O)

Besides low serum vitamin B12, elevated methylmalonic acid (MMA) is often seen with B12 deficiency

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Enzymes modifying ferulic acid (COMT, F5H) also have elevated expression in LY46, suggesting more active lignin formation in LY46 at early exposure to stress

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Chromatin regulators Chromatin regulators such as BRD4 and HMGA1 serve as epigenetic modulators of autophagy by influencing transcriptional accessibility and chromatin architecture at ATG loci