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This section summarizes the most influential clinical trials in immunotherapy and cell/gene-based approaches for type 1 diabetes (T1D), with particular emphasis on their reported efficacy and the remaining feasibility challenges

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Smac promotes caspase-3 and -7 activation by neutralizing inhibitor of apoptosis proteins (IAPs), including cIAP-1, cIAP-2, and XIAP [53]

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In modern clinical and animal studies, they have been found to be very effective in the treatment of PCOS and also slightly improve IR by alleviating inflammation, remodeling intestinal homeostasis, or by regulating the PI3K/Akt signaling pathway, among other mechanisms (311314)