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During adolescence there is a significant decrease in the gray matter volume and density in the prefrontal cortex, parietal cortex and basal ganglia, which are critical brain regions for executive function, sensory processing, and motivation ( A functional MRI study examined the effects of nicotine dependence and tobacco consumption on brain structural changes in young adolescents and found that nicotine dependence was associated with distinct atrophy patterns on the brain volume ( Studies have shown that micro-circuitry of the PFC and the NAc show developmental differences in dopamine function indicating that that cognitive processing within these regions is profoundly different in adolescence as compared to adulthood ( Smoking during adolescence increases the risk of developing psychiatric disorders and cognitive impairment in later life ( Nicotine Induced Neurobiological Changes in Adolescents Comparison of smoking behavior of adolescents with that of adult's point to an enhanced sensitivity of the adolescent brain to addictive properties of nicotine
Cannabis smoke condensate I: the effect of different preparation methods on tetrahydrocannabinol levels
MS has also been recently associated with changes of the intestinal microbiota with the study reporting depletion in species belonging to Clostridium and Bacteroidetes in Japanese patients with MS [184]
