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Conclusion: Tolerance of simvastatin 20mg/day during lead-in and the study drug (40mg/day or placebo) in a cohort of patients with cirrhosis with CSPH has been excellent with no evidence of direct drug-induced hepatotoxicity, few confirmed cases of statin-induced muscle injury, no cases of rhabdomyolysis, and no deaths related to study medication Disclosures: David Kaplan: AstraZeneca Inc: Grant/Research Support, Roche Genentech: Independent Contractor, Exact Sciences: Grant/Research Support, Glycotest: Grant/Research Support, Sirtex: Advisor, Exelixis: Advisor, AstraZeneca: Advisor, Rajni Mehta: Nothing to Disclose, Alexander Burdzy: Nothing to Disclose, Sofia Lizza: Nothing to Disclose, Gyorgy Baffy: Nothing to Disclose, Ruben Hernaez: Nothing to Disclose, Alexander Monto: Nothing to Disclose, George Ioannou: Nothing to Disclose, Kristel Hunt: Nothing to Disclose, Tae Hoon Lee: Merck & Co., Inc.: Chapter Authorship of Merck Manual, Salix Pharmaceuticals, Inc