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effects on fat metabolism in humans are still being characterised and should not be overstated Glucagon receptor increases energy expenditure and promotes fat breakdown, though it may also raise hepatic glucose output

Targeted Deletion of the Gene Encoding Iron Regulatory Protein-2 Causes Misregulation of Iron Metabolism and Neurodegenerative Disease in Mice

109 Moreover, mice with cardiac expression of a dnPI3K p110 mutant had blunted cardiac hypertrophic adaptations to swimming exercise

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Wang Z, Chen JQ, Liu JL, Tian L