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Additionally, oxidative changes can deactivate enzymes and structural proteins, limiting cell activity

Oxcarbazepine, a derivative of carbamazepine that has better safety and tolerability, has also been reported to be effective in improving pain associated with DPN [69,70]

Maccarrone and Ullrich suggested that the consideration of the redox state may be more reflective of the physiologically and pathological effects of oxidative stress than the mere absolute amounts of antioxidants and oxidants

However, a direct demonstration would require conditional, fibroblast-specific IL-1R1 knockout and quantification of monocyte and granulocyte infiltration