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doi: 10.1016/J.CCELL.2017.06.003 13 VerhaakRGWHoadleyKAPurdomEWangVQiYWilkersonMDet al

Targeting mitochondria and subsequent activation of AMPK are considered the hinge of pleiotropic actions of metformin [389]

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Participants are usually divided into groups receiving varying dosages of MSM, with regular monitoring to assess any changes in health status, side effects, and overall efficacy

On the other hand, when housed at the thermoneutral temperature, their body temperature remained normal, and their sleep duration, sleep patterns, and time spent in each sleep stage were similar to the control mice