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Description

Novel CHOP activator LGH00168 inhibits the NF-B pathway and induces ROS-mediated ER stress, leading to necroptosis in A549 human lung cancer cells (177)

Luo J, Uchida K, Shi R

It is characterized by chronic dysfunction of the RPE, accumulation of drusen beneath the RPE, and progressive atrophy of the underlying choriocapillaris, which provides oxygen and nutrients to photoreceptor cells