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one study found that the belief that heated tobacco products are less harmful to either themselves or others was the most important factor behind their use in Japan The Global State of Smoking Poll 2019, carried out by Global Action to End Smoking (formerly the Foundation for a Smoke-Free World), found the most common reason Japanese smokers switched from cigarettes to HTP was due to concern about the health risks to others associated with second-hand smoke from cigarettes (40%).[12] This was followed by 36% who said HTP may not be as bad for their own health, and 35% who said they could use HTP in places where smoking was not allowed

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Furthermore, in vitro, macrophage polarization between M1 and M2 phenotypes is influenced by iron levels, with iron overload conditions leading to a M2 anti-inflammatory phenotype and suppression of the M1 pro-inflammatory phenotype [102]

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Excessive alcohol use can contribute to being overweight, which increases the risk of several types of cancer