cicplatin and glutathione Overcoming resistance to cisplatin by inhibition of S-transferases (GSTs) with ethacraplatin micelles in vitro in vivo A structure-based mechanism of cisplatin

Common causes: Oxidative stress demanding increased glutathione production Heavy detoxification burden (toxins, alcohol, medications) Low protein/methionine intake (especially in vegans/vegetarians) CBS gene mutations causing rapid conversion to cysteine Paradoxically, severe B-vitamin deficiencies Chronic inflammation or infection Malnutrition or eating disorders Health concerns associated with low homocysteine: Oxidative stress insufficient antioxidant reserves despite high demand Chronic inflammation ongoing immune activation and tissue damage Protein deficiency inadequate amino acid intake Impaired methylation not enough homocysteine to recycle into SAMe Detoxification overload liver working overtime Cardiovascular issues yes, even low homocysteine can contribute to atherosclerosis through different mechanisms Muscle wasting in severe cases with malnutrition Neurological problems from chronic oxidative damage Treatment approach: Increase protein intake, especially methionine-rich foods Address underlying oxidative stress and inflammation Support glutathione production directly (NAC, glycine, glutamine) Reduce toxic burden and support detoxification Address root causes (infections, mold, chronic illness) May need to temporarily avoid high-dose methylated B vitamins The goal: Address why homocysteine is being depleted rather than simply trying to raise levels

(95) Tu, H

Historically, high-functioning autism (HFA) and Aspergers syndrome were considered separate diagnoses, but since 2013, both are now encompassed under autism spectrum disorder (ASD) in the DSM-5 classification

Yarkta M, Dner F, Doru H, Aynal G, Ynden Z, Deliba N

B9 and B12 are two of the Bs that you just shouldnt go without if youre planning to welcome a new B (baby!) to your family

E.ManzoniM