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In a sex-stratified analysis, we found that the relationship between TL and Responder status was only observed for female participants ( p = 0.037) but not males ( p = 0.147) while the relationship with PSS was observed in male ( p = 0.014) but not female ( p = 0.118) participants (Supplementary Table 1), although these sex differences must be interpreted cautiously due to the small number of subjects when sex-dichotomized

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p = 0.58), indicating that the participants, on average, were slightly but not statistically significant younger than expected at baseline

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