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PMID: 24717514 Genetic NNMT knockdown (not 5-Amino-1MQ) protected mice from diet-induced obesity

NNMT metabolizes nicotinamide into 1-methylnicotinamide (MNA), diverting it away from the NAD+ salvage pathway

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12-week progression-free survival rate (12-week PFS rate) was 23.8%, and diarrhea, loss of appetite, high blood pressure, gastric bleeding and protein urine and other adverse events were reported