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Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi

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The patients (mean age: 52 years) were treated either with an 8-week intervention of high cocoa liquor/polyphenol rich chocolate or simulated iso-calorific chocolate (cocoa liquor free/low polyphenols) with a wash-out period of 2-weeks followed by an 8-week intervention of other chocolate

Status: Early-phase human trials Not commercially available SC injection (research settings) Caveat: Strong mechanistic case

Autoreactive IgGs in Sjgrens disease are most commonly of the IgG1, IgG2, and IgG3 subclass [203]