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For instance, LePHGPX in transgenic tobacco plants protected against DNA fragmentation, membrane integrity loss, and oxidative stress induced by necrotrophic fungi, mirroring anti-apoptotic roles observed in animals ( Ferroptosis, a form of iron-dependent lipid peroxidation-mediated cell death, was first described in animals and is regulated by GPX4 (Seibt et al., 2019

Concomitantly, expanded adipose tissue synthesizes and secretes huge amounts of cytokines and chemokines, collectively defined adipochemokines or adipokines, such as leptin, that promote infiltration of adipose tissue by macrophages with subsequent overproduction of RO(N)S and inflammatory cytokines, leading to adipose tissue inflammation (21, 22)

This study aimed to explore the protective effects of theaflavins against liver damage caused by iron overload and to elucidate the underlying molecular mechanisms, with a particular emphasis on ferroptosis

While DFP has demonstrated the capacity to reduce mitochondrial iron overload and mitigate oxidative stress in preclinical models, its clinical application highlights a critical challenge

Erythrocytes play a crucial role in the regulation of eNOS-derived nitric oxide (NO) bioavailability, acting as scavengers of this critical vasodilator with an effect on vascular tone and blood flow [45]

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