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These data support an effect of IL-13 to decrease total and reduced GSH through high 15LO1, PEBP1, and GPX4 activity, which is partially compensated by (a) increased expression/activity of SLC7A11 to enhance new intracellular GSH production and (b) increased export of GSSG

To alleviate nausea and vomiting, it is advised to stay hydrated and eat a mild diet until the symptoms improve

In addition, ascorbic acid is a cofactor for several enzymes, such as dopamine B-monooxygenase or prolyl 4-hydroxylase and lysyl hydroxylase [303]

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FIGURE 1 Concerning dimerization, the GSTU dimer has an open V-shaped configuration with 2200 2 of the accessible surface that is buried at the interface, comparable with that of GSTOs (2000 2 ), but smaller than that of GSTFs (2700 2 ) and most other classes of GSTs (28003400 2 ) (Table 3)

ACS Appl Mater Interfaces (2021) 13(23):2675969