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doi: 10.1152/advan.00080.2014 51

Clinical Update 1/29/2026 Alpha-Lipoic Acid Overdose Extremely high doses of alpha-lipoic acid (ALA) can be dangerous -- learn more in our Alpha-Lipoic Acid Supplements Review

Yet, the only reported effect of KD administered in vivo on bone marrow stem cell (BMSC) isolates is reduced ALP activity and extracellular matrix (ECM) mineralization after 7 days of BMSC osteogenic culture 13,22