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It has been demonstrated that the missense variant NQO1, found in 4-20% of the human population, results in no detectable NQO1 activity due to rapid degradation of the NQO1 P187S protein

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Jadavji NM, Farr TD, Lips J, Khalil AA, Boehm-Sturm P, Foddis M, Harms C, Fchtemeier M, Dirnagl U

Proc Natl Acad Sci USA 101 , 77117715, (2004)

Tumor volumes were calculated by using the formula V = ( D d 2 )/2 mm 3 , where D is the largest diameter and d is the shortest diameter