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We used to believe really strongly that alcohol could be protective, and now, not so much at all. Revisiting the data The CCSAs new guidance for alcohol use are, for many people, surprising

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Epidermolytic keratinopathic ichthyosis due to a pathogenic variant in the KRT10 gene

This study can only examine causation, which is not clear enough regarding coffee consumption and smoking to provide a reliable reference, such as the amount of coffee or smoke that does not alter clozapine concentration