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however, a previous analysis has suggested that the actual prevalence may be 10 times this estimate, most likely because of underdiagnosis (8)

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This was accompanied by HMGB1 and PD-L1 upregulation, suggesting that ferroptosis enhances immune activation while modulating checkpoint signals

Rather than using expression vectors which contain viral origins of replication, host cells can be transformed with DNA controlled by appropriate expression control elements (e.g., promoter, enhancer, sequences, transcription terminators, polyadenylation sites, etc.), and a selectable marker

However, the detection of measurable PETCT signals is challenging owing to the minute fraction of viable DTPs likely surviving in most tumours

doi: 10.1007/BF00027124 69 HsuP