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From the list of 15 proteins involved in metabolism, ROS homeostasis, and apoptosis, only a handful seem to be (1) regulated by reversible S-glutathionylation and (2) display altered S-glutathionylation patterns in various pathologies (Mailloux et al., 2013a)

doi: 10.1016/j.biochi.2007.01.012 8 BenrahmouneM.ThrondP.AbedinzadehZ

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We are proposing to amend 42 CFR 412.87 to reflect this proposal by redesignating current paragraph (e) as paragraph (f) and adding a new provision at 42 CFR 412.87(e) to state that CMS will only consider, for add-on payments for a particular fiscal year, an application for which the medical service or technology is either FDA market authorized for the indication that is the subject of the new technology add-on payment application or for which the medical service or technology is the subject of a complete and active FDA marketing authorization request and documentation of FDA acceptance or filing is provided to CMS at the time of new technology add-on payment application submission