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By activating FXRs in both the intestine and the liver, OCA is hypothesized to lessen liver exposure to toxic bile acids, leading to anti-inflammatory and anti-fibrotic effects [99,100]

10.1016/j.chembiol.2008.02.010 167 YangY.ChenJ.GaoQ.ShanX.WangJ.LvZ

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In diabetischen Ratten, die bekanntlich eine stark verzoegerte Wundheilung aufweisen, zeigte die PIC-Behandlung erhoehte Glutathion- und Ascorbinsaeurespiegel, verbesserte Epithelialisierung sowie eine gesteigerte Aktivierung von Fibroblasten und Mastzellen im Wundgebiet

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Data Analysis : Guideline methodologists performed meta-analysis when appropriate with RevMan software and the Cochrane Risk of Bias tool to assess risk of biased results based on use of concealment of allocation, blinding, incomplete outcome data reporting, selective reporting and other potential biases