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The therapeutic benefits of curcumin for these neurodegenerative diseases appear multifactorial via regulation of transcription factors, cytokines and enzymes associated with (Nuclear factor kappa beta) NFB activity

14 LopatkinA

10.1016/j.tibs.2015.05.001 144 PfaffenbachK

Geissoschizine methyl ether is a potent antagonist at 5-HT 1A receptors 19,21,22 and exhibits a similar free -methoxyacrylate group to that of speciogynine, the motif that significantly increases the affinity of speciogynine at 5-HT 1A Rs relative to mitragynine (Figure 4)