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Vascular endothelial growth factor (VEGF) is the predominant and critical angiogenic protein, binding to its receptor on ECs to promote their proliferation and migration by activating the phosphoinositide 3-kinase-protein kinase B (PI3K-Akt) signaling pathway and the Ras-extracellular signal-regulated kinases1/2 (Ras-Erk1/2) signaling pathway

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