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Intestine and gastrointestinal system The historical context of BPC-157 (isolated from gastric juice) explains its most documented gastrointestinal application: gastric ulcers, colitis, and Crohn's disease in animal models

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Conversely, either germline knockout or antisense oligonucleotide knockdown of FGFR4 expression in mice enhances hepatic fat oxidation, glucose metabolism, and insulin sensitivity (308310) while reducing hepatic steatosis (308, 309)