bacterial and host-derived glutathione are required to activate prfa Allosteric GSH binding primes for DNA binding. (A B) RCSB PDB - 5LRS: The

RCSB PDB 5LRS: The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with glutathione and a 30 bp operator PrfA box motif Diverse roles of low molecular weight thiol GSH in Francisella's virulence, location sensing and GSH stealing from host ScienceDirect Multiple regulatory check points control prfA expression and protein Download Scientific Diagram Structural insights into glutathione mediated activation of the master regulator PrfA in Listeria monocytogenes Protein & Cell Springer Nature Link Listeria monocytogenes utilizes glutathione and limited inorganic sulfur compounds as sources of essential cysteine Infection and Immunity Glutathione Provides a Source of Cysteine Essential for Intracellular Multiplication of Francisella tularensis PLOS Pathogens

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