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Interestingly, about one third of people with IBS have anxiety symptoms, suggesting a potential shared gutbrain inflammatory axis between GAD and IBS (Grover et al., 2021)

This leaves you open to oxidative damage caused by reactive oxygen species (aka free radicals)

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On the other hand, the K63-linked polyubiquitin chain participates in endosomal trafficking, signal transduction and DNA repair but not in protein degradation 2,3,10

Key takeaways for histamine intolerance: Histamine intolerance is caused by an imbalance of too much histamine compared to your capacity to break it down

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